I am spending the academic year 2019-20 on sabbatical as a fellow at the Wissenschaftkolleg zu Berlin where I am the Director of Oxford in Berlin. Before taking sabbatical leave I served as Pro-Vice-Chancellor (Head of Brexit Strategy), having previously been Head of the Medical Sciences Division and Dean of Medicine from 2008 to 2017. I am Professor of Stroke Medicine at the University of Oxford in the Radcliffe Department of Medicine, an Honorary Consultant Neurologist at the John Radcliffe Hospital and Professorial Fellow in Medicine at Corpus Christi College.
I head the Laboratory of Cerebral Ischaemia whose aim is to identify novel neuroprotective strategies that could be used to protect the brain during reperfusion treatment of acute stroke using either thrombolysis or endovascular thrombectomy. I conduct preclinical studies on putative neuroprotectants in models of stroke, while running human studies to identify potential targets for treatment strategies using imaging markers for monitoring patients. I take a multimodal approach that involves aspects of cell and molecular biology, physiology, pharmacology, in vivo imaging, surgery and clinical medicine.
Research and Teaching
My interests currently lie in many exciting avenues of stroke research, including identifying and targeting novel neuroprotective pathways following brain ischaemia such as the mammalian targets of rapamycin (mTOR), the oxygen sensing mechanism, hypoxia inducible factor (HIF) using proteomic and metabolomic techniques to identify new biomarkers for stroke. Other avenues of research include investigating neurovascular coupling following stroke, exploring pericyte control of capillary blood flow as well as attempting to improve the efficacy of approved treatments for acute stroke, recombinant tissue plasminogen activator (rtPA) and endovascular thrombectomy.
Hadley G, Beard DJ, Couch Y, Neuhaus AA, Adriaanse B, Deluca GC, Sutherland BA, Buchan AM. Rapamycin for ischemic stroke: Old drug, new tricks? 2019. Journal of Cerebral Blood Flow and Metabolism.39(1):20-35
Beard DJ, Hadley G, Thurley N, Howells DW, Sutherland BA, Buchan AM. The effect of rapamycin treatment on cerebral ischaemia: A systematic review and meta-analysis of animal model studies. 2019. International Journal of Stroke. 14(2):137-145.
Hadley G, Neuhaus AA, Couch Y, Beard DJ, Adriaanse BA, Vekrellis K, DeLuca GC, Papadakis M, Sutherland BA, Buchan AM. The role of the endoplasmic reticulum stress response following cerebral ischemia. Int J Stroke. 2018 13(4):379-390.
Sutherland BA, Fordsmann JC, Martin C, Neuhaus AA, Witgen BM, Piilgaard H, Lønstrup M, Couch Y, Sibson NR, Lauritzen M, Buchan AM. Multi-modal assessment of neurovascular coupling during cerebral ischaemia and reperfusion using remote middle cerebral artery occlusion. J Cereb Blood Flow Metab 2017 37(7):2494-2508.
Neuhaus AA, Couch Y, Sutherland BA, Buchan AM. Novel method to study pericyte contractility and responses to ischaemia in vitro using electrical impedance. J Cereb Blood Flow Metab 2017 37(6):2013-2024.
Neuhaus AA, Couch Y, Hadley G, Buchan AM. Neuroprotection in stroke: the importance of collaboration and reproducibility. Brain 2017 140(8):2079-2092.
Nagel S, Sinha D, Day D, Reith W, Chapot R, Papanagiotou P, Warburton EA, Guyler P, Tysoe S, Fassbender K, Walter S, Essig M, Heidenrich J, Konstas AA, Harrison M, Papadakis M, Greveson E, Joly O, Gerry S, Maguire H, Roffe C, Hampton-Till J, Buchan AM, Grunwald IQ. e-ASPECTS software is non-inferior to neuroradiologists in applying the ASPECT score to computed tomography scans of acute ischemic stroke patients. Int J Stroke 2017 12(6):615-622.
Howarth C, Sutherland B, Choi HB, Martin C, Lind BL, Khennouf L, LeDue J, Pakan JM, Ko RW, Ellis-Davies G, Lauritzen M, Sibson NR, Buchan AM, MacVicar BA. A Critical Role for Astrocytes in Hypercapnic Vasodilation in Brain. J Neurosci 2017 37(9):2403-2414.
Balami JS, White PM, McMeekin PJ, Ford GA, Buchan AM. Complications of endovascular treatment for acute ischemic stroke: Prevention and management. Int J Stroke 2017 13(4):348-361.
Sutherland BA, Neuhaus AA, Couch Y, Balami JS, DeLuca GC, Hadley G, Harris SL, Grey AN, Buchan AM. The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke. 2016. Journal of Cerebral Blood Flow and Metabolism. 36(2), 363–369.
Balami JS, Sutherland BA, Edmunds LD, (...), DeLuca GC, Buchan AM. A systematic review and meta-analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke 2015. International Journal of Stroke. 10(8), pp. 1168-1178.
Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O’Farrell FM, Buchan AM, Lauritzen M, Attwell D. Capillary pericytes regulate cerebral blood flow in health and disease. Nature, 2014 Apr 3;508(7494):55-60.
Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM. The exact science of stroke thrombolysis and the quiet art of patient selection. Brain, 2013 136(Pt 12):3528-53.
Sutherland BA, Buchan AM. Alteplase treatment does not increase brain injury after mechanical middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab. 2013 33(11):e1-7.
Hadley G, De Luca GC, Papadakis M, Buchan AM. Endogenous neuroprotection: Hamartin modulates an austere approach to staying alive in a recession. Int J Stroke. 2013 8(6):449-50.
Papadakis M, Hadley G, Xilouri M, Hoyte LC, Nagel S, McMenamin MM, Tsaknakis G, Watt SM, Drakesmith CW, Chen R, Wood MJ, Zhao Z, Kessler B, Vekrellis K, Buchan AM. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat Med 2013 19(3):351-7.
Chen RL, Nagel S, Papadakis M, Bishop T, Pollard P, Ratcliffe PJ, Pugh CW, Buchan AM. Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice. J Physiol, 2012 15;590(16):4079-91.
Sutherland BA, Minnerup J, Balami JS, Arba F, Buchan AM, Kleinschnitz C. Neuroprotection for ischaemic stroke: translation from the bench to the bedside. Int J Stroke 2012 7(5):407-18.
Nagel S, Papadakis M, Chen R, Hoyte LC, Brooks KJ, Buchan AM, Gallichan D, Sibson NR, Pugh C. Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats J Cereb Blood Flow Metab, 2011 31(1):132-43.
Attwell D, Buchan AM, Charpak S, Lauritzen M, MacVicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature 2010;468(7321):232-43.