Corpus Christi College Oxford

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Professor Alastair Buchan

Alastair Buchan

Professorial Fellow in Medicine

Professor Buchan is the Pro-Vice-Chancellor (Head of Brexit Strategy) at the University of Oxford. A Neurologist and Neuroscientist in Stroke Medicine since 1986, he is Professor of Stroke Medicine at the University of Oxford in the Nuffield Department of Medicine of the John Radcliffe Hospital where he is an Honorary Consultant Neurologist. He is a Professorial Fellow at Corpus Christi College, Oxford.

He was educated at Repton School, Cambridge, Oxford and Harvard. He undertook clinical medical training at Oxford and Neurology Specialist training in Oxford, London, Ontario, and Cornell University Medical College in New York. Since completing his training, he has worked at the University of Western Ontario, University of Ottawa, and University of Calgary. He has been a Consultant Neurologist at University Hospital in London, the Civic Hospital in Ottawa, and the Foothills Hospital in Calgary where he held the Heart and Stroke Foundation Professorship in Stroke.

In Oxford since 2005, he has established an Acute Stroke Programme and has been the Translational Research Director for the UK Stroke Research Network. He is the Director of the new Acute Vascular Imaging Centre, and was the founding Director of the Oxford NIHR Biomedical Research Centre. He became Head of the Medical Sciences Division of the University of Oxford on October 1st 2008. He is a Fellow of the Academy of Medical Sciences (FMedSci), a Senior Investigator of the NIHR and holds a DSc from the University of Oxford.

He sits on the board of the Berlin Health Institute and Charité Hospital Stroke Programme in Berlin. He is the Senior Member of the Osler House Club in Oxford and a Member of the Athenaeum Club in London. He is currently a Governor of Repton School.

He was awarded an honorary degree of Laws (LLD) from the University of Calgary in May 2009.

Research Interests
Professor Buchan's research interests are in Thrombolysis and Neuroprotection for Stroke. His laboratory focuses on selective neuronal vulnerability and understanding mechanisms that might lead to neuroprotection in the clinic. His clinical research interests are in managing hyperacute stroke and effective prevention following TIA. He has run a number of trials including CASES and FASTER.

Teaching and Supervision
Professor Buchan teaches students Neuroscience, Neurology and Stroke. He supervises medical students, trainees and fellows on the Stroke Unit. He also lectures to departments in the faculty of Physiological Sciences about Neuroprotection and Stroke. He supervises DPhil students in his laboratory.

Sample of Recent PublicationsBalami JS, White PM,, McMeekin PJ,, Ford GA,, Buchan AM. Complications of endovascular treatment for acute ischemic stroke: Prevention and management. Int J Stroke. 2017

  1. Hadley G, Neuhaus AA, Couch Y, Beard DJ, Adriaanse BA, Vekrellis K, DeLuca GC, Papadakis M, Sutherland BA, Buchan AM. The role of the endoplasmic reticulum stress response following cerebral ischemia. Int J Stroke. 2017
  2. Neuhaus AA, Couch Y, Hadley G, Buchan AM. Neuroprotection in stroke: the importance of collaboration and reproducibility. Brain. 2017
  3. Howarth C, Sutherland B, Choi HB, Martin C, Lind BL, Khennouf L, LeDue J, Pakan JM, Ko RW, Ellis-Davies G, Lauritzen M, Sibson NR, Buchan AM, MacVicar BA. A Critical Role for Astrocytes in Hypercapnic Vasodilation in Brain. J Neurosci. 2017
  4. Nagel S, Sinha D, Day D, Reith W, Chapot R, Papanagiotou P, Warburton EA, Guyler P, Tysoe S, Fassbender K, Walter S, Essig M, Heidenrich J, Konstas AA, Harrison M, Papadakis M, Greveson E, Joly O, Gerry S, Maguire H, Roffe C, Hampton-Till J, Buchan AM, Grunwald IQ. e-ASPECTS software is non-inferior to neuroradiologists in applying the ASPECT score to computed tomography scans of acute ischemic stroke patients. Int J Stroke. 2017
  5. Sutherland BA, Fordsmann JC, Martin C, Neuhaus AA, Witgen BM, Piilgaard H, Lønstrup M, Couch Y, Sibson NR, Lauritzen M, Buchan AM. Multi-modal assessment of neurovascular coupling during cerebral ischaemia and reperfusion using remote middle cerebral artery occlusion. J Cereb Blood Flow Metab. 2017
  6. Neuhaus AA, Couch Y, Sutherland BA, Buchan AM. Novel method to study pericyte contractility and responses to ischaemia in vitro using electrical impedance. J Cereb Blood Flow Metab. 2017 
  7. Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM. The exact science of stroke thrombolysis and the quiet art of patient selection. Brain, 2013
  8.  Sutherland BA, Buchan AM. Alteplase treatment does not increase brain injury after mechanical middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab. 2013
  9. Hadley G, De Luca GC, Papadakis M, Buchan AM. Endogenous neuroprotection: Hamartin modulates an austere approach to staying alive in a recession. Int J Stroke. 2013
  10. Papadakis M, Hadley G, Xilouri M, Hoyte LC, Nagel S, McMenamin MM, Tsaknakis G, Watt SM, Drakesmith CW, Chen R, Wood MJ, Zhao Z, Kessler B, Vekrellis K, Buchan AM. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat Med,  2013
  11. Chen RL, Nagel S, Papadakis M, Bishop T, Pollard P, Ratcliffe PJ, Pugh CW, Buchan AM. Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice. J Physiol, 2012
  12. Sutherland BA, Minnerup J, Balami JS, Arba F, Buchan AM, Kleinschnitz C. Neuroprotection for ischaemic stroke: translation from the bench to the bedside. Int J Stroke, 2012
  13. Nagel S, Papadakis M, Chen R, Hoyte LC, Brooks KJ, Buchan AM, Gallichan D, Sibson NR, Pugh C. Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats J Cereb Blood Flow Metab, 2011
  14. Attwell D, Buchan AM, Charpak S, Lauritzen M, MacVicar BA, Newman EA. Glial and neuronal control of brain blood flow Nature. 2010.



updated 11/1/18

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