Corpus Christi College Oxford

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Professor Alastair Buchan

Alastair Buchan

Professorial Fellow in Medicine

Biography
Professor Buchan is the Head of the Medical Science Division (Dean of the Medical School) at the University of Oxford. A Neurologist and Neuroscientist in Stroke Medicine since 1986, he is Professor of Stroke Medicine at the University of Oxford in the Nuffield Department of Medicine of the John Radcliffe Hospital where he is an Honorary Consultant Neurologist. He is a Professorial Fellow at Corpus Christi College, Oxford.

He was educated at Repton School, Cambridge, Oxford and Harvard. He undertook clinical medical training at Oxford and Neurology Specialist training in Oxford, London, Ontario, and Cornell University Medical College in New York. Since completing his training, he has worked at the University of Western Ontario, University of Ottawa, and University of Calgary. He has been a Consultant Neurologist at University Hospital in London, the Civic Hospital in Ottawa, and the Foothills Hospital in Calgary where he held the Heart and Stroke Foundation Professorship in Stroke.

In Oxford since 2005, he has established an Acute Stroke Programme and has been the Translational Research Director for the UK Stroke Research Network. He is the Director of the new Acute Vascular Imaging Centre, and was the founding Director of the Oxford NIHR Biomedical Research Centre. He became Head of the Medical Sciences Division of the University of Oxford on October 1st 2008. He is a Fellow of the Academy of Medical Sciences (FMedSci), a Senior Investigator of the NIHR and holds a DSc from the University of Oxford.

He serves as a member of Council of the University of Oxford. In addition he is currently a Governor of Repton School, a Trustee of the Jenner Institute, a Nuffield Medical Trustee, and sits on the board of the Charité Hospital Stroke Programme in Berlin. He is the Senior Member of the Osler House Club in Oxford and a Member of the Athenaeum Club in London.

He was awarded an honorary degree of Laws (LLD) from the University of Calgary in May 2009.

Research Interests
Professor Buchan's research interests are in Thrombolysis and Neuroprotection for Stroke. His laboratory focuses on selective neuronal vulnerability and understanding mechanisms that might lead to neuroprotection in the clinic. His clinical research interests are in managing hyperacute stroke and effective prevention following TIA. He has run a number of trials including CASES and FASTER.

Teaching and Supervision
Professor Buchan teaches students Neuroscience, Neurology and Stroke. He supervises medical students, trainees and fellows on the Stroke Unit. He also lectures to departments in the faculty of Physiological Sciences about Neuroprotection and Stroke. He supervises DPhil students in his laboratory.

Sample of Recent Publications
1. Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM. 2013. The exact science of stroke thrombolysis and the quiet art of patient selection. Brain, [Sep 14, Epub ahead of print]
2. Sutherland BA, Buchan AM. 2013. Alteplase treatment does not increase brain injury after mechanical middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab. [Aug 21, Epub ahead of print]
3. Hadley G, De Luca GC, Papadakis M, Buchan AM. 2013. Endogenous neuroprotection: Hamartin modulates an austere approach to staying alive in a recession. Int J Stroke, 8 (6), 449-50
4. Papadakis M, Hadley G, Xilouri M, Hoyte LC, Nagel S, McMenamin MM, Tsaknakis G, Watt SM, Drakesmith CW, Chen R, Wood MJ, Zhao Z, Kessler B, Vekrellis K, Buchan AM. 2013. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat Med, 19 (3), 351-7
5. Chen RL, Nagel S, Papadakis M, Bishop T, Pollard P, Ratcliffe PJ, Pugh CW, Buchan AM. 2012. Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice. J Physiol, 590 (Pt 16), 4079-91
6. Sutherland BA, Minnerup J, Balami JS, Arba F, Buchan AM, Kleinschnitz C. 2012. Neuroprotection for ischaemic stroke: translation from the bench to the bedside. Int J Stroke, 7 (5), 407-18
7. Sutherland BA, Papadakis M, Chen R-L, Buchan AM. 2011. Cerebral blood flow alteration in neuroprotection following cerebral ischaemia. J Physiol, 589 (Pt 17), 4105-14
8. Nagel S, Papadakis M, Chen R, Hoyte LC, Brooks KJ, Buchan AM, Gallichan D, Sibson NR, Pugh C. 2011. Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats Journal of Cerebral Blood Flow and Metabolism, 31 (1), 132-43
9. Attwell D, Buchan AM, Charpak S, Lauritzen M, MacVicar BA, Newman EA. 2010. Glial and neuronal control of brain blood flow Nature, 468 (7321), 232-43
10. Harston GWJ, Sutherland BA, Kennedy J, Buchan AM. 2010. The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: A review of rtPA neurotoxicity Journal of Cerebral Blood Flow and Metabolism, 30 (11), 1804-16

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